Variantes genéticas relacionadas à atividade física ou ao sedentarismo: uma revisão sistemática (2021)

Abstract Background: Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour can improve causal inference in physical activity research. The aim of this systematic review was to provide an updated overview of the evidence of genetic […]
Lipidômica cerebral como um campo em ascensão no contexto das doenças neurodegenerativas: perspectiva com o aprendizado de máquina (2021)

Abstract Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked to the etiology, progression, and severity of neurodegenerative […]
Biofilmes gastrointestinais na saúde e na doença (2021)

Abstract Microorganisms colonize various ecological niches in the human habitat, as they do in nature. Predominant forms of multicellular communities called biofilms colonize human tissue surfaces. The gastrointestinal tract is home to a profusion of microorganisms with intertwined, but not identical, lifestyles: as isolated planktonic cells, as biofilms and in biofilm-dispersed form. It is therefore […]
Medicina personalizada na doença de Chron (2021)

Abstract Similar to many immune-mediated diseases, Crohn’s disease follows a relapsing-remitting pattern, with a variable disease course and heterogeneous clinical outcomes. Frequency of flare-ups, development of complications, and response to treatment collectively determine the effect on a patient’s quality of life, which can vary from minimal disruption to profound disability or death. Despite recent advances […]
Poluentes e qualidade do esperma: uma revisão sistemática e metanálise (2021)

Abstract Male fertility and semen quality have declined over recent decades. Among other causes, exposure to environmental and occupational pollution has been linked to adverse reproductive outcomes, but effects on male semen quality are still uncertain. Therefore, the aim of the present study was to conduct a systematic review and meta-analysis to assess current evidence […]