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Genetic variants related to physical activity or sedentary behaviour: a systematic review (2021)

Abstract Background: Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour can improve causal inference in physical activity research. The aim of this systematic review was to provide an updated overview of the evidence of genetic

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Brain lipidomics as a rising field in neurodegenerative contexts: Perspectives with Machine Learning approaches (2021)

Abstract Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked to the etiology, progression, and severity of neurodegenerative

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Gastrointestinal biofilms in health and disease (2021)

Abstract Microorganisms colonize various ecological niches in the human habitat, as they do in nature. Predominant forms of multicellular communities called biofilms colonize human tissue surfaces. The gastrointestinal tract is home to a profusion of microorganisms with intertwined, but not identical, lifestyles: as isolated planktonic cells, as biofilms and in biofilm-dispersed form. It is therefore

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Personalised medicine in Crohn’s disease (2021)

Abstract Similar to many immune-mediated diseases, Crohn’s disease follows a relapsing-remitting pattern, with a variable disease course and heterogeneous clinical outcomes. Frequency of flare-ups, development of complications, and response to treatment collectively determine the effect on a patient’s quality of life, which can vary from minimal disruption to profound disability or death. Despite recent advances

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Pollutants and sperm quality: a systematic review and meta-analysis (2021)

Abstract Male fertility and semen quality have declined over recent decades. Among other causes, exposure to environmental and occupational pollution has been linked to adverse reproductive outcomes, but effects on male semen quality are still uncertain. Therefore, the aim of the present study was to conduct a systematic review and meta-analysis to assess current evidence

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Temas inovadores sobre a medicina na era pós-genômica fizeram parte do International Lifestyle & Personalized Medicine Summit

Congresso online de medicina integrativa trouxe palestrantes renomados no meio científico e contou com a presença do ilustre Jeffrey Bland, conhecido como “pai” da medicina personalizada. Nos dias 26 e 27 de novembro, mais de 300 médicos e nutricionistas de diversos países e de todo o Brasil aprofundaram seus conhecimentos sobre medicina personalizada e do

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Microbioma, neuroinflamação e comportamento humano

Distúrbios comportamentais: doenças do século? Os distúrbios comportamentais e os transtornos mentais vêm crescendo exponencialmente no cenário de saúde. A OMS (Organização Mundial da Saúde) classifica a depressão como uma condição mental do século, doença que afeta 322 milhões de pessoas no mundo, sendo que no Brasil os números chegam a 11,5 milhões. Segundo estimativas

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Epigenética, mito-hormose e meio ambiente: a relação com a longevidade!

Senilidade x longevidade Nas últimas décadas, houve aumento da expectativa de vida da população, porém, ao mesmo tempo, há um maior número de pessoas doentes, principalmente com doenças crônicas, aquelas que irão perdurar por muito tempo, impactando a qualidade de vida e aumentando a fragilidade do indivíduo com o decorrer dos anos. Assim, é errôneo

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